DNA Dynamics: An Investigation Combining Ultrafast Spectroscopy and Large-Scale Computer Simulation

Dr. Mark A. Berg

Department of Chemistry and Biochemistry
University of South Carolina

Abstract

  DNA is an unusual molecule—both highly structured and highly flexible. Understanding its dynamics starts with very fundamental issues: Which motions are important to think about? Are these motions active on femtosecond, picosecond or nanosecond time scales? Can an analogy be made between DNA and better known systems, or are DNA’s dynamics unique? These questions have been addressed using an ultrafast spectroscopic technique to measure the dynamics of the electric fields within the DNA helix. These measurements show the characteristic features of DNA dynamics, but simulations are needed to relate electric-field dynamics to more specific molecular motions. In collaboration with the Ponomarev and Beveridge, we have shown that highly perturbed water near the DNA causes highly unusual dynamics in DNA.

Tuesday, September 23rd, 3:00pm
101 Stanley Thomas Hall
Tulane University, Uptown.