Seminars People Information Computing Research
Project II: Integrative Modeling of Bone Adaptation - Incorporation of Hierarchical Time and Length Scales
P.I.s: Hart (Biomedical Engineering), Nauman (Biomedical Engineering)
Osteoporosis is often described as a dynamic imbalance in the activity of osteoblasts, bone forming cells, and osteoclasts, cells that dissolve bone tissue. This imbalance creates regions of low bone mass with an architecture that is poorly suited to its mechanical function and leads to a dramatically increased fracture risk. The development of effective therapies requires an understanding of local effects including cellular-level phenomena and the effects of mechanical loading and damage as well as system effects such as parathyroid hormone and estrogen levels in the bloodstream. Perhaps even more importantly, these processes occur over many different time scales and the full effects of osteoporosis may not become apparent for decades.
The goal of this development project is to more fully understand how the cellular processes of bone deposition and bone resorption lead to tissue-level and organ-level bone structure. Towards this end computational models that incorporate hierarchical length and time scales must be developed, calibrated with existing experimental and in vivo results, and then tested to see if they can predict clinical outcomes. This project will thus directly link the mechanical behavior of bone generation at the cellular and macroscale levels to molecular (hormonal) stimuli. For this project, Professor Nauman (an experienced cell/tissue biomedical engineer) will collaborate with Professor Hart, an expert in the use of the finite-element method for computing bone remodeling processes.
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Tulane Tulane University
201 Lindy Boggs Center
Computational Science
6823 St. Charles Ave.
New Orleans, LA 70118